New article in PNAS!​

Mitochondrial dynamics Newarticle in PNAS! Learn More Mfn2-dependent fusion pathway of PE-enriched micron-sized vesicles

European South Atlantic Biophysical (ESAB) congress was a total success.

Subheading Your MainHeading Here Learn More sub-heading Main Heading Lorem ipsum dolor sit amet, consectetur adipiscing elit. Quisque eget nunc placerat turpis lacinia consectetur. Fusce aliquet placerat lacus ac convallis. Nullam commodo arcu felis.  A first achievement by the MML was the first reconstitution of active ATP synthases into Giant Unilamellar Vesicles [7]. Upon rotation, ATP synthases promote large non-equilibrium fluctuations at discrete hot spots compatible with an accumulation of proteins at highly curved membrane sites. A direct demonstration of a curvature−protein coupling was recently observed by the active sorting of ATP synthases in curvature gradients using micromanipulation and tube pulling experiments [8]. The curvature-seeking behavior of rotating ATP synthases might be sustained by a weak membrane-mediated attractive interaction produced by a hydrophobic mismatch upon protein rotation. The formation of transient protein dimers produces a conic-like arrangement of proteins leading to the dynamic coupling between protein shape and membrane curvature. The MML is currently exploring the dynamic behavior of rotating ATP synthases when embedded in phase-separated membranes and in membrane viscosity gradients.